Little Horn uproots three of the ten horns on the terrible beast.

These Gothic tribes; 1.  Vandals,   2.  Ostrogoths, and   3.  Heruli, did not believe in the Trinity. In 538, the Eastern Roman Emperor, Justinian, in cooperation with the Pope, thrust the Ostrogoths out of the city of Rome. They became extinct somewhere around 554-556 AD.  In 538 A.D., the Pope took possession of the city of Rome after the Emperor Justinian decreed that the Pope should be the head of all the Christian churches and have power to prosecute heresy, which gave him power over the people of God.

Daniel 7:20   And of the ten horns that were in his head, and of the other which came up, and before whom three fell, even of the horn that had eyes, and a mouth that spake very great things, whose look was more stout than his fellows.